The fourth installment in the Pirates of the Caribbean series adventure fantasy film released in 3D.
After a failed attempt to rescue his former first mate, Joshamee Gibbs, Captain Jack Sparrow is brought before King George II, who wants Jack to guide an expedition to the Fountain of Youth before the Spanish locate it. Heading the expedition is Jack's old nemesis, Captain Hector Barbossa who is now a privateer in service to the British Navy after having lost Jack's ship, the Black Pearl, as well as his leg.
Jack escapes, but his father, Captain Teague finds him and warns Jack about the Fountain's tests. He also reveals that someone is impersonating Jack that is Angelica, Jack's former lover and daughter of the ruthless pirate Blackbeard, who possesses supernatural powers.
Jack is taken aboard Blackbeard's ship, the Queen Anne's Revenge, and forced to lead the way to the Fountain and to find two silver chalices that once belonged to Juan Ponce de León, both of which are believed to be aboard his lost ship. The Fountain's water must be drunk simultaneously from the two chalices. The person drinking from the chalice containing a mermaid's tear has his life extended, while the other person dies, his years of life drained from his body. Meanwhile, Gibbs, having memorized and destroyed Sparrow's map, barters with Barbossa to guide him to the Fountain
When Sparrow finds the grounded, decaying vessel, Barbossa is waiting inside: the Spanish have already taken the chalices. However, Barbossa only seeks revenge against Blackbeard for capturing the Black Pearl which forced Barbossa to amputate his own leg to escape. He and Jack join forces to defeat Blackbeard, then head to the nearby Spanish camp to steal the chalices. Meanwhile, Syrena, who returns Philip's love, is tricked into shedding a tear, which Blackbeard collects, then leaves her to die while forcing Philip to go with him. Sparrow returns with the chalices and Gibbs, whom he had reunited with while helping Barbossa. Jack negotiates with Blackbeard to return his confiscated magical compass and letting Gibbs go free in exchange for the chalices and his leading them to the Fountain. Blackbeard agrees and Gibbs departs with Jack's compass.
At the Fountain, Blackbeard and his crew are attacked by Barbossa, then the Spanish, sent by their king to destroy the Fountain, believing its power is an abomination against God. After an intense battle, Barbossa stabs Blackbeard with a poison-laced sword that Angelica accidentally cuts herself on. Barbossa claims Blackbeard's magical sword, and assuming command, leaves with Blackbeard's crew. Philip, though mortally wounded, escapes and returns to free Syrena. After finding the chalices that the Spaniards had tossed into deep water, Syrena gives them to Jack, then retrieves the dying Phillip, taking him underwater to save his life.
As both Blackbeard and Angelica lay dying, Blackbeard wants his daughter to sacrifice herself to save him. Angelica willingly agrees, but Jack secretly switches the cups, giving her the one containing Syrena's tear, thus sparing her life and killing Blackbeard. Despite declaring their love, Jack, knowing Angelica may want to avenge her father's death, strands her on an island, intending for a passing ship to pick her up. Meanwhile, Barbossa, who now commands the Queen Anne's Revenge, renounces his ties to the crown and reverts to piracy. Jack finds Gibbs, who used Jack's compass to locate the Revenge and retrieve the Black Pearl, as well as other captured ships that Blackbeard had magically shrunk and bottled. The two head off, hoping to find a way to return the Pearl to her original size.